Metallic-Polyphenolic Nanoparticles Reinforced Cationic Guar Gum Hydrogel for Effectively Treating Burn Wound.

The development of injectable hydrogel dressings which are long-term moisturizing, easy-to-apply, and effectively inhibiting infection and inflammatory is essential to promote burn wound repairing. Herein, we develop an injectable hydrogel with moisturizing, antibacterial and anti-inflammation abilities via multiple reversible interactions between cation guar gum (CG) and metallic-polyphenolic nanoparticles (PA-Zn II NPs). Specifically, PA-Zn II NPs is formed by synergistic complexation of protocatechualdehyde (PA) and zinc ion (Zn 2+ ), provides CGPZ hydrogel with plentiful reversible interactions to inhibit the loss of moist. By interacting with PA-Zn II NPs, the CGPZ hydrogel can provide enhanced moisturization for more than 3 days. Moreover, the CGPZ hydrogel can maintain good adhesion for a period of time with injection and self-healing capabilities due to reversible interactions between CG and PA-Zn II NPs. In addition, CGPZ hydrogel exhibit outstanding broad spectrum antibacterial performance, as its killing efficiency against Escherichia coli and Staphylococcus aureus are all greater than 99.99%. Importantly, compared with commercial dressing, the CGPZ hydrogel can promote wound healing faster by inhibiting tissue damage from dysregulated inflammation and accelerating neovascularization. We believe that the moisturizing CGPZ hydrogel with anti-bacterial and anti-inflammation performance can serve as a promising dressing for the effectively treatment of burn wound. This article is protected by copyright. All rights reserved.