Delayed alveolar bone repair and osteonecrosis associated with Zoledronic Acid therapy in rats: macroscopic, microscopic and molecular analysis.

Gustavo Zanna FerreiraEdson Virgílio Zen FilhoIzabel Regina Fischer Rubira-Bullen Gustavo Pompermaier Garlet Carlos Ferreira Dos Santos Paulo Sérgio da Silva Santos

Published in: Journal of applied oral science : revista FOB (2020)

The results highlighted strong and evident interference of zoledronic acid in bone repair of the socket, causing osteonecrosis and delayed bone remodeling.

Keyphrases

bone mineral density
soft tissue
bone loss
bone regeneration
postmenopausal women
stem cells
body composition
smoking cessation