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Delayed alveolar bone repair and osteonecrosis associated with Zoledronic Acid therapy in rats: macroscopic, microscopic and molecular analysis.

Gustavo Zanna FerreiraEdson Virgílio Zen FilhoIzabel Regina Fischer Rubira-BullenGustavo Pompermaier GarletCarlos Ferreira Dos SantosPaulo Sérgio da Silva Santos
Published in: Journal of applied oral science : revista FOB (2020)
The results highlighted strong and evident interference of zoledronic acid in bone repair of the socket, causing osteonecrosis and delayed bone remodeling.
Keyphrases
  • bone mineral density
  • soft tissue
  • bone loss
  • bone regeneration
  • postmenopausal women
  • stem cells
  • body composition
  • smoking cessation