Semi-physiological Enriched Population Pharmacokinetic Modelling to Predict the Effects of Pregnancy on the Pharmacokinetics of Cytotoxic Drugs.

J M JanssenDavid DamoiseauxJ G C van HasseltF C H AmantK van CalsterenJ H BeijnenA D R HuitemaT P C Dorlo

Published in: Clinical pharmacokinetics (2023)

By incorporating gestational changes into existing population pharmacokinetic models, it is possible to adequately predict plasma concentrations of drugs in pregnant patients which may inform dose adjustments in this population.

Keyphrases

pregnant women
end stage renal disease
newly diagnosed
ejection fraction
preterm birth
pregnancy outcomes
body mass index
patient reported