Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study.
Leigh F JohnsonMargaret T MayRob E DorringtonMorna CornellAndrew BoulleMatthias EggerMary-Ann DaviesPublished in: PLoS medicine (2017)
ART has had a dramatic impact on adult mortality in South Africa, but delays in the rollout of ART, especially in the early stages of the ART programme, have contributed to substantial loss of life. This is the first study to our knowledge to calibrate a model of ART impact to population-level recorded death data in Africa; models that are not calibrated to population-level death data may overestimate HIV-related mortality.
Keyphrases
- hiv infected
- south africa
- antiretroviral therapy
- hiv positive
- cardiovascular events
- human immunodeficiency virus
- risk factors
- healthcare
- hiv infected patients
- electronic health record
- big data
- clinical trial
- hepatitis c virus
- coronary artery disease
- men who have sex with men
- cardiovascular disease
- study protocol
- deep learning
- artificial intelligence
- childhood cancer