Effect of HLA-DRB1 alleles and genetic variants on the development of neutralizing antibodies to interferon beta in the BEYOND and BENEFIT trials.

Dorothea BuckTill F M AndlauerWilmar IglEva-Maria WickleinMark MühlauFrank WeberKarl KöchertChristoph PohlBarry ArnasonGiancarlo ComiStuart CookMassimo FilippiHans-Peter HartungDouglas JefferyLudwig KapposFrederik BarkhofGilles EdanMark S FreedmanXavier MontalbánBertram Müller-MyhsokBernhard Hemmernull null

Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2018)

The contribution of HLA alleles and HLA-associated single-nucleotide polymorphisms (SNPs) to the development and titer of antibodies against interferon β was confirmed in the combined analysis of two multi-national, multi-center studies.

Keyphrases

dendritic cells
genome wide
gene expression
quality improvement
dna methylation