A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8.

Francesca Nardelli Michela Ghitti Giacomo Quilici Alessandro Gori Qingqiong Luo Andrea Berardi Angelina Sacchi Matteo Monieri Bergamaschi GretaWolfgang BermelFuxiang Chen Angelo Corti Flavio Curnis Giovanna Musco

Published in: Chemical communications (Cambridge, England) (2020)

Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications.

Keyphrases

magnetic resonance
high resolution
high throughput
machine learning
anti inflammatory
solid state
iron oxide