RIPK3 causes mitochondrial dysfunction and albuminuria in diabetic podocytopathy through PGAM5-Drp1 signaling.
Jeong Suk KangNam-Jun ChoSeong Woo LeeJeong Geon LeeJi-Hye LeeJawoon YiMin Sun ChoiSamel ParkHyo-Wook GilJoon Cheol OhSeung Seob SonMi Ju ParkJong-Seok MoonDonghyeong LeeSo-Young KimSeung-Hoon YangSang Soo KimEun Soo LeeChoon Hee ChungJihwan ParkEun Young LeePublished in: Metabolism: clinical and experimental (2024)
The study demonstrates that RIPK3 reflects deterioration of renal function of DKD. In addition, RIPK3 induces diabetic podocytopathy by regulating mitochondrial fission via PGAM5-Drp1 signaling through MLKL. Inhibition of RIPK3 might be a promising therapeutic option for treating DKD.