The influence of apical periodontitis on circulatory inflammatory mediators in peripheral blood: A prospective case-control study.
Athina Christina GeorgiouJos W R TwiskWim CrielaardPeter OuwerlingArjan H SchoneveldSuzette Veronica van der WaalPublished in: International endodontic journal (2022)
The immunologic profile of chronic AP in one tooth and its healing profile reveals a systemic low-grade inflammation through compensatory immunosuppression. A larger lesion or multiple lesions could disrupt the balance that the system is trying to maintain, resulting in loss of homeostasis.