Pancreatic ductal cells may have a negative effect on human islet transplantation.

Sandra Marín-CañasElisabet Estil LesLaura LladoPatricia San JoséMontserrat NacherNoèlia TéllezEduard Montanya

Published in: PloS one (2019)

Islet preparations enriched with ductal cells have a lower insulin stimulation index in vitro and achieved a worse metabolic outcome after transplantation. Inflammation may mediate the deleterious effects of ductal cells on islet cells.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
endothelial cells
stem cells
cell death
adipose tissue
skeletal muscle
insulin resistance
weight loss
induced pluripotent stem cells