Pharmacological Mechanisms of Tinglizi against Chronic Heart Failure Determined by Network Pharmacology and Molecular Docking.

Liangtao LuoHaowen WangGuowei HuangLu ZhangXiuwei LiChongyang Ma Xing Wang

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

-sitosterol, isorhamnetin, and so on. The action targets are beta 2-adrenergic receptor (ADRB2), heme oxygenase 1 (HMOX1), and so on. The main pathways are advanced glycation end products/receptor for advanced glycation end products (AGE-RAGE) signaling pathway in diabetic complications, hypoxia-inducible factor (HIF-1) signaling pathway, estrogen signaling pathway, and so on. They play an integrated role in the treatment of CHF.

Keyphrases

signaling pathway
molecular docking
pi k akt
epithelial mesenchymal transition
induced apoptosis
molecular dynamics simulations
type diabetes
risk factors
combination therapy