Microbial function and genital inflammation in young South African women at high risk of HIV infection.
Arghavan AlisoltaniMonalisa T ManhanzvaMatthys PotgieterChristina BalleLiam BellElizabeth RossArash IranzadehMichelle du PlessisNina RadzeyZac McDonaldBridget CalderImane AllaliNicola MulderSmritee DabeeShaun BarnabasHoyam GamieldienAdam GodzikJonathan M BlackburnDavid L TabbLinda-Gail BekkerHeather B JaspanJo-Ann S PassmoreLindi MassonPublished in: Microbiome (2020)
Both the presence of specific microbial taxa in the FGT and their properties and activities are critical determinants of FGT inflammation. Our findings support those of previous studies suggesting that peptidoglycan is directly immunosuppressive, and identify a possible avenue for biotherapeutic development to reduce inflammation in the FGT. To facilitate further investigations of microbial activities, we have developed the FGT-DB application that is available at http://fgtdb.org/ . Video Abstract.