Head-to-Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study.
David N Soleimani-MeigooniRuben SmithKarine ProvostOrit H Lesman-SegevIsabel Elaine AllenMiranda K ChenHanna ChoLauren EdwardsShorena JanelidzeRenaud La JoieNidhi MundadaRik OssenkoppeleErik StomrudOlof StrandbergAmelia StromAdam L BoxerJeffrey L DageMaria Luisa Gorno-TempiniJoel H KramerBruce L MillerJulio C RojasHoward J RosenChul H LyooOskar HanssonGil D RabinoviciPublished in: Annals of neurology (2024)
Amyloid- and tau-PET visual reads have similar sensitivity/specificity for detecting AD in cognitively impaired patients. Visual tau-PET interpretations requiring cortical binding outside MTL increase specificity, but lower sensitivity for MCI-AD. ANN NEUROL 2024;96:476-487.