BNT162b2 mRNA COVID-19 Vaccine Does Not Impact the Honeymoon Phase in Type 1 Diabetes: A Case Report.
Marco InfanteAndrea FabbriNathalia PadillaFrancesca PacificiPasquale Di PernaLaura VitielloAlessandra FeracoMaria GiulianoMarina PasseriMassimiliano CaprioCamillo RicordiDavid Della-MorteLuigi UccioliPublished in: Vaccines (2022)
Type 1 diabetes (T1D), which is caused by the autoimmune destruction of insulin-secreting pancreatic beta cells, represents a high-risk category requiring COVID-19 vaccine prioritization. Although COVID-19 vaccination can lead to transient hyperglycemia (vaccination-induced hyperglycemia; ViHG), its influence on the course of the clinical remission phase of T1D (a.k.a. "honeymoon phase") is currently unknown. Recently, there has been an increasing concern that COVID-19 vaccination may trigger autoimmune phenomena. We describe the case of a 24-year-old young Italian man with T1D who received two doses of the BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccine during a prolonged honeymoon phase. He experienced a transient impairment in glucose control (as evidenced by continuous glucose monitoring) that was not associated with substantial changes in stimulated C-peptide levels and islet autoantibody titers. Nonetheless, large prospective studies are needed to confirm the safety and the immunometabolic impact of the BNT162b2 vaccine in T1D patients during the honeymoon phase. Thus far, T1D patients who are going to receive COVID-19 vaccination should be warned about the possible occurrence of transient ViHG and should undergo strict postvaccination surveillance.
Keyphrases
- coronavirus disease
- sars cov
- type diabetes
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- multiple sclerosis
- respiratory syndrome coronavirus
- glycemic control
- cardiovascular disease
- peritoneal dialysis
- risk assessment
- prognostic factors
- induced apoptosis
- patient reported outcomes
- metabolic syndrome
- insulin resistance
- rheumatoid arthritis
- systemic lupus erythematosus
- blood pressure
- cell death
- brain injury
- binding protein
- oxidative stress
- blood brain barrier