A Phenome-Wide Association Study of Drugs and Comorbidities Associated With Gastrointestinal Dysfunction in Systemic Sclerosis.

Rory H MacleanFiza AhmedVoon H OngCharles D MurrayChristopher P Denton

Published in: The Journal of rheumatology (2023)

Using a hypothesis-free PheWAS approach, we replicated known, and revealed potential novel, risk factors for SSc-GI dysfunction, including drug classes such as opioid, antimuscarinic, and endothelin receptor antagonist, and ANA subgroup.

Keyphrases

systemic sclerosis
interstitial lung disease
oxidative stress
chronic pain
pain management
single cell
emergency department
drug induced
clinical trial
idiopathic pulmonary fibrosis
open label