Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma.

Lei ChenHeng LuDunfa PengLong Long CaoFarah BalloutKannappan SrirmajayamZheng ChenAjaz BhatTimothy C WangAnthony CapobiancoJianwen QueOliver Gene McDonaldAlexander ZaikaShutian ZhangWael El-Rifai

Published in: Gut (2022)

These findings underscore a unique mechanism that links redox balance, inflammation and embryonic development (NOTCH) into a common pro-tumorigenic pathway that is intrinsic to EAC cells.

Keyphrases

induced apoptosis
oxidative stress
signaling pathway
cell cycle arrest
squamous cell carcinoma
cell proliferation
pi k akt
cell death
nuclear factor
locally advanced
radiation therapy
inflammatory response
rectal cancer
toll like receptor