Mixed histiocytic disorders: Nature versus nurture?
Kenneth L McClainPeter DimitrionPublished in: British journal of haematology (2024)
Histiocytic diseases arise from MAPK mutations in myeloid progenitors. Depending on whether the progenitor follows a dendritic cell or macrophage/monocyte lineage the final histology results in Langerhans cell histiocytosis, Rosai-Dorfman disease or Erdheim-Chester disease. Commentary on: Friedman et al. Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic mutations and responses to targeted therapy. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19462.
Keyphrases
- dendritic cells
- single cell
- regulatory t cells
- signaling pathway
- oxidative stress
- immune response
- adipose tissue
- clinical trial
- acute myeloid leukemia
- social media
- bone marrow
- endothelial cells
- stem cells
- gene expression
- cell therapy
- cell proliferation
- peripheral blood
- health information
- mesenchymal stem cells
- pi k akt
- double blind
- cell fate