Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications.
Yuri I GolovinDmitry Yu GolovinKsenia Yu VlasovaMaxim M VeselovAzizbek D UsvalievAlexander V KabanovNatalia L KlyachkoPublished in: Nanomaterials (Basel, Switzerland) (2021)
The review discusses the theoretical, experimental and toxicological aspects of the prospective biomedical application of functionalized magnetic nanoparticles (MNPs) activated by a low frequency non-heating alternating magnetic field (AMF). In this approach, known as nano-magnetomechanical activation (NMMA), the MNPs are used as mediators that localize and apply force to such target biomolecular structures as enzyme molecules, transport vesicles, cell organelles, etc., without significant heating. It is shown that NMMA can become a biophysical platform for a family of therapy methods including the addressed delivery and controlled release of therapeutic agents from transport nanomodules, as well as selective molecular nanoscale localized drugless nanomechanical impacts. It is characterized by low system biochemical and electromagnetic toxicity. A technique of 3D scanning of the NMMA region with the size of several mm to several cm over object internals has been described.
Keyphrases
- atomic force microscopy
- magnetic nanoparticles
- high resolution
- single molecule
- cell therapy
- high speed
- molecularly imprinted
- single cell
- oxidative stress
- working memory
- high throughput
- high frequency
- current status
- quantum dots
- stem cells
- mesenchymal stem cells
- oxide nanoparticles
- mass spectrometry
- electron microscopy
- bone marrow
- solid phase extraction