Postnatal inflammation in ApoE-/- mice is associated with immune training and atherosclerosis.
Ellesandra C NoyeSiroon BekkeringAlbert P LimawanMaria U NguyenLisa K WidiasmokoHui LuSalvatore PepeMichael M CheungTrevelyan R MenheniottMegan J WallaceTimothy J MossDavid P BurgnerKirsty R ShortPublished in: Clinical science (London, England : 1979) (2021)
Postnatal inflammation results in a trained phenotype in atherosclerosis-prone mice that is not enhanced by prenatal inflammation. If analogous mechanisms occur in humans, then there may be novel early life opportunities to reduce CVD risk in infants with early life infections.