Blood-based biomarkers of human papillomavirus-associated cancers: A systematic review and meta-analysis.
Sanjana BalachandraSamuel B KusinRebecca LeeJames-Michael BlackwellJasmin A TiroLindsay G CowellCheng-Ming ChiangShwu-Yuan WuSanskriti VarmaErika L RiveraHelen G MayoLianghao DingBaran D SumerJayanthi S LeaAditya BagrodiaLinda M FarkasRichard C WangCarole A FakhryKristina R DahlstromErich M SturgisAndrew T DayPublished in: Cancer (2020)
HPV-16 E6 antibodies and circulating HPV-16 DNA are the most robustly analyzed and most promising blood-based biomarkers for HPV-associated cancers to date. Comparative validity analyses are warranted. Variations in tumor type-specific, high-risk HPV DNA prevalence according to anatomic site and world region highlight the need for biomarkers targeting more high-risk HPV types. Further investigation of blood-based microRNA expression profiling appears indicated.