Prospective study of serum and ionized magnesium pharmacokinetics in the treatment of children with severe acute asthma.

Sarah M BeckerKathleen M JobKelly LimaTy J ForbesJadon WagstaffNam K TranCatherine M SherwinDouglas S NelsonMichael D JohnsonJoseph E Rower

Published in: European journal of clinical pharmacology (2018)

This prospective study supports and extends our previous PK analysis of total serum magnesium concentrations. Ionized and total serum magnesium followed similar PK profiles following IV MgSO4 administration in children. A single bolus infusion of IV MgSO4 was safe in this small sample of children receiving it for acute asthma.

Keyphrases

young adults
chronic obstructive pulmonary disease
lung function
respiratory failure
allergic rhinitis
smoking cessation
extracorporeal membrane oxygenation
mechanical ventilation