JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling.

Published in: Epigenetics & chromatin (2018)

We show that JARID2 and the PRC2 complex regulate muscle differentiation by modulating Wnt signaling through the direct repression of Wnt antagonists.

Keyphrases

skeletal muscle
insulin resistance
stem cells
signaling pathway
type diabetes
metabolic syndrome