Login / Signup

The impact of alcohol and illicit substance use on the pharmacokinetics of first-line TB drugs.

Marie WijkKamunkhwala GausiSamantha MalatestaSarah E WeberRichard CourtBronwyn MyersTara CarneyCharles D H ParryCharles R HorsburghLaura F WhiteLubbe WiesnerRobin M WarrenCaitlin UrenHelen M McIlleronFrank KloproggePaolo DentiKaren R Jacobson
Published in: The Journal of antimicrobial chemotherapy (2024)
No clinically relevant effect of alcohol use was observed on the pharmacokinetics of first-line TB drugs, suggesting that poor treatment outcome is unlikely due to pharmacokinetic alterations. That methaqualone reduced rifampicin means dose adjustment may be beneficial.
Keyphrases
  • mycobacterium tuberculosis
  • pulmonary tuberculosis
  • drug induced