ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma.

Jia XieTeneema KuriakoseBrandon BianskiNathaniel TwarogEvan SavageKe XuXiaoyan ZhuChen HeBaranda HansenHong WangAnthony HighYuxin LiJerold E RehgHeather S TillmanBurgess B FreemanZoran RankovicArzu Onar-ThomasYiping FanGang WuJunmin PengShondra MillerSuzanne J BakerAnang A ShelatChristopher L Tinkle

Published in: Neuro-oncology (2023)

Our study supports the clinical evaluation of AZD1390 in combination with radiation in pediatric patients with HGG.

Keyphrases

high grade
low grade
dna damage
radiation induced
radiation therapy
dna damage response
childhood cancer