Electroacupuncture Alleviates Cerebral Ischemia-reperfusion Injury by Regulating the S1PR2/TLR4/NLRP3 Signaling Pathway via m6A Methylation of lncRNA H19.
Han-Rui ZhangGu-Quan MaHe-Qun LvYao-Ting FengYong-Jun PengPublished in: Current neurovascular research (2024)
The findings indicated that EA might down-regulate the S1PR2/TLR4/NLRP3 signaling pathway via m6A methylation of lncRNA H19 to alleviate CIR injury. Our findings provide a new insight into the molecular mechanism of EA on CIR injury.
Keyphrases
- signaling pathway
- ischemia reperfusion injury
- toll like receptor
- pi k akt
- inflammatory response
- immune response
- genome wide
- dna methylation
- epithelial mesenchymal transition
- long non coding rna
- long noncoding rna
- oxidative stress
- nlrp inflammasome
- induced apoptosis
- subarachnoid hemorrhage
- cerebral ischemia
- nuclear factor
- gene expression
- spinal cord
- spinal cord injury
- blood brain barrier