Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes.

Bethany M BarnesLouisa NelsonAnthony TigheGeorge J BurghelI-Hsuan LinSudha DesaiJoanne C McGrailRobert D MorganStephen S Taylor

Published in: Genome medicine (2021)

This robust classification informs the selection of the most appropriate models for all five histotypes. Following further refinement on larger training cohorts, the transcriptional classification may represent a useful tool to support the classification of new model systems of OC subtypes.

Keyphrases

deep learning
machine learning
gene expression
transcription factor
public health
heat shock protein