Dickkopf-1 Can Lead to Immune Evasion in Metastatic Castration-Resistant Prostate Cancer.
David R WiseJeffrey A SchneiderJoshua ArmeniaVictor Adorno FeblesBridget McLaughlinRyan BrennanKatie L ThorenWassim AbidaKaren S SfanosAngelo M De MarzoSrinivasan YegnasubramanianJosef J FoxMichael HaasHeidi HeathMichael H KageyWalter NewmanCynthia A SirardMartin FleisherMichael J MorrisYu ChenSteven M LarsonMichael C HaffnerPeter S NelsonNikolaus SchultzMichael J GarabedianHoward I ScherSusan K LoganCharles L Sawyersnull nullPublished in: JCO precision oncology (2020)
These results support DKK1 as a contributor to the immunosuppressive tumor microenvironment of DNPC. These data have provided the rationale for a clinical trial targeting DKK1 in mCRPC (ClinicalTrials.gov identifier: NCT03837353).