The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors Are Associated with Interleukin-6.
Shatha Rouf MoustafaKhalid F Al-RawiDrozdstoy St StoyanovArafat Hussein Al-DujailiThitiporn SupasitthumrongHussein Kadhem Al-HakeimMichael MaesPublished in: Diagnostics (Basel, Switzerland) (2020)
the EOS contributes to SCZ symptomatology, neurocognitive impairments and a non-response to treatment. In SCZ, EOS peptides/receptors may exert CIRS functions, whereas increased KOR levels may contribute to the pathophysiology of SCZ and EM2 and KOR to a non-response to treatment.