In vitro silencing of RIP2 in naive CD4 + T cells from lupus-prone mice promotes pathogenic Th17 cell differentiation.

Zi-Cheng Song Shu-Ting Liu Xue-Ying Xia Jia-Jia Hu Rui-Xue Leng Wei Zhao

Published in: Clinical rheumatology (2024)

T cells preferentially differentiate towards pTh17 cells rather than cTh17 cells in vitro. • Inhibition of RIP2 may be involved in the development of SLE via effects on Th17/IL-17.

Keyphrases

induced apoptosis
systemic lupus erythematosus
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
signaling pathway
cell death
type diabetes
metabolic syndrome
rheumatoid arthritis
adipose tissue
cell proliferation
insulin resistance