Genetic predisposition & evolutionary traces of pediatric cancer risk: A prospective 5-year population-based genome sequencing study of children with CNS tumors.

Ulrik Kristoffer StoltzeJon Foss-SkiftesvikThomas van Overeem HansenAnna ByrjalsenAstrid SehestedDavid ScheieTorben Stamm MikkelsenSimon RasmussenMads BakHenrik OkkelsMichael Thude CallesenJane Skjøth-RasmussenAnne-Marie GerdesKjeld SchmiegelowRené MathiasenKarin Wadt

Published in: Neuro-oncology (2022)

∽10% of pediatric CNS tumors can be attributed to rare variants in known cancer genes. Genes associated with high risk of childhood cancer show evolutionary evidence of constraint.

Keyphrases

childhood cancer
genome wide
young adults
copy number
dna methylation
blood brain barrier
papillary thyroid
single cell
squamous cell carcinoma