Radiotherapy alone as a possible de-intensified treatment for human papillomavirus-related locally advanced oropharyngeal squamous cell carcinoma.
Yoshifumi YamamotoNorihiko TakemotoTakahiro MichibaYuji SeoFumiaki IsohashiKeisuke OtaniMotoyuki SuzukiTakashi FujiiTadashi YoshiiKenji MitaniToshimichi YasuiHironori ChoYasuhiko TomitaEiichi MoriiTeruki TeshimaKazuhiko OgawaHidenori InoharaPublished in: International journal of clinical oncology (2019)
Survival in p16-positive locally advanced OPSCC differs depending on HPV DNA status. Radiotherapy alone can serve as a de-intensified treatment for p16-positive/HPV DNA-positive locally advanced OPSCC, but not for p16-positive/HPV DNA-negative locally advanced OPSCC.
Keyphrases
- locally advanced
- squamous cell carcinoma
- rectal cancer
- neoadjuvant chemotherapy
- radiation therapy
- phase ii study
- circulating tumor
- high grade
- single molecule
- cell free
- early stage
- nucleic acid
- lymph node metastasis
- radiation induced
- combination therapy
- open label
- cervical cancer screening
- circulating tumor cells
- replacement therapy