Hollow Copper Sulfide Nanosphere-Doxorubicin/Graphene Oxide Core-Shell Nanocomposite for Photothermo-chemotherapy.
Lu HanYa-Nan HaoXing WeiXu-Wei ChenYang ShuJian-Hua WangPublished in: ACS biomaterials science & engineering (2017)
A novel core-shell nanostructure, hollow copper sulfide nanosphere-doxorubicin (DOX)/graphene oxide (GO) (CuS-DOX/GO), is constructed for the purpose of controlled drug delivery and improved photothermo-chemotherapeutic effect. The CuS-DOX/GO nanocomposite is configured by employing dual photothermal agents, where the core, hollow CuS nanoparticle, acts as delivery-carrier for doxorubicin, and the shell, PEGylated GO nanosheet, prohibits leakage of the drug. DOX can be efficiently loaded onto the hollow CuS nanoparticles, and its subsequent release from CuS-DOX/GO nanocomposite is triggered in a pH- and near-infrared light-dependent manner. Moreover, integration of the two photothermal agents significantly improves the photothermal performance of this system. Ultimately, the combination of phototherapy and chemotherapy based on this system results in a much higher HeLa cell killing efficacy with respect to that for a single chemotherapy mode, as demonstrated by in vitro cytotoxicity tests.
Keyphrases
- drug delivery
- cancer therapy
- drug release
- molecularly imprinted
- solid phase extraction
- reduced graphene oxide
- locally advanced
- metal organic framework
- highly efficient
- quantum dots
- photodynamic therapy
- carbon nanotubes
- chemotherapy induced
- cell therapy
- visible light
- single cell
- wastewater treatment
- liquid chromatography
- high resolution
- oxide nanoparticles
- adverse drug
- simultaneous determination