HPLC-DAD finger printing, antioxidant, cholinesterase, and α-glucosidase inhibitory potentials of a novel plant Olax nana.
Muhammad OvaisMuhammad AyazAli Talha KhalilSayed Afzal ShahMuhammad Saeed JanAbida RazaMuhammad ShahidZabta Khan ShinwariPublished in: BMC complementary and alternative medicine (2018)
This study investigated Olax nana for the first time for detailed qualitative phytochemical tests, HPLC-DAD finger printing analysis, antioxidant, anticholinesterase and α-glucosidase inhibition assays. The antioxidant and cholinesterase inhibitory results were considerable and can provide scientific basis for further studies on the neuroprotective and anti-Alzheimer's potentials of this plant. ON-Cr may further be subjected to fractionation and polarity guided fractionation to narrow down the search for isolation of bioactive compounds.
Keyphrases
- ms ms
- simultaneous determination
- oxidative stress
- anti inflammatory
- molecular docking
- high performance liquid chromatography
- tandem mass spectrometry
- solid phase extraction
- mass spectrometry
- high throughput
- cognitive decline
- liquid chromatography
- cell wall
- blood brain barrier
- high resolution
- cerebral ischemia
- subarachnoid hemorrhage
- plant growth