Unveiling Vaginal Fibrosis: A Novel Murine Model Using Bleomycin and Epithelial Disruption.
Jennifer M McCrackenGisele A CalderonLishore A KumarSwathi BalajiFelipe RivasDorothea ErxlebenAdam HallJulie Ce HakimPublished in: bioRxiv : the preprint server for biology (2023)
Epithelial disruption combined with bleomycin induces murine vaginal fibrosis within three weeks, characterized by increased collagen synthesis. Remarkably, the vaginal tissue fully recovers within six weeks, elucidating the regenerative capacity of the vagina.