Genetic Determinants of Survival in Parkinson's Disease in the Asian Population.

Chunyu LiYanbing HouRuwei OuXiaojing GuYongping ChenLingyu ZhangKuncheng LiuJunyu LinBei CaoQianqian WeiXueping ChenWei SongBi ZhaoYing WuYiyuan CuiHui Fang Shang

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

These findings improve the current understanding of the genetic cause of survival of PD and provide a novel target RPL3 for further research on PD pathogenesis and potential therapeutic options. Our results also demonstrate the potential utility of PRS of survival in identifying patients with shorter survival and providing personalized clinical monitoring and treatment. © 2022 International Parkinson and Movement Disorder Society.

Keyphrases

free survival
genome wide
copy number
risk assessment
dna methylation
combination therapy
human health
smoking cessation