Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease.
Wenxu PanLi XiangXinhua LiangWenjun DuJunhong ZhaoSong ZhangXuan ZhouLanlan GengSitang GongWanfu XuPublished in: Mediators of inflammation (2023)
These findings demonstrated that highly expressed VTN disrupted IECs differentiation through PDE4-mediated ferroptosis in IBD, suggesting targeting PDE4 could be a promising therapeutic strategy for patients with IBD.