DPPA4 increases aggressiveness of pituitary neuroendocrine tumors by enhancing cell stemness.

Shaista ChaudharyUjjal DasShaima JabbarOmkaram GangisettyBénédicte RousseauSimon HanftDipak K Sarkar

Published in: Neuro-oncology (2024)

These findings support a role of DPPA4 in tumor stemness and aggressiveness and provide a preclinical rationale for modulating this stemness regulator for the treatment of PitNETs.

Keyphrases

stem cells
neuroendocrine tumors
epithelial mesenchymal transition
cell therapy
cancer stem cells
signaling pathway
clinical trial
smoking cessation