Covalent organic framework-engineered polydopamine nanoplatform for multimodal imaging-guided tumor photothermal-chemotherapy.

Peng GaoRuyue WeiXiaohan Liu Yuanyuan ChenTong WuMingwan ShiMengzhen WangNa Li Bo Tang

Published in: Chemical communications (Cambridge, England) (2021)

A covalent organic framework (COF)-engineered polydopamine core-shell nanoplatform (PDA@COF) was developed. The ultrasmall pores and abundant functional sites of the COF endowed the nanoplatform with enhanced drug loading capacity and diminished drug leakage effect. Multimodal imaging-guided photothermal chemo-synergistic tumor-targeted therapy was realized after rational functionalization. This work offers new insights for developing COF-based multifunctional theranostic systems.

Keyphrases

cancer therapy
photodynamic therapy
drug delivery
fluorescence imaging
drug release
high resolution
pain management
locally advanced
adverse drug
emergency department
magnetic nanoparticles
squamous cell carcinoma
chronic pain
rectal cancer
metal organic framework
electronic health record