Target attainment and population pharmacokinetics of flucloxacillin in critically ill patients: a multicenter study.
Sjoerd D MeenksNieko C PuntJos L M L le NobleNorbert A FoudraineKees NeefPaddy Koen Camiel JanssenPublished in: Critical care (London, England) (2023)
Based on our dosing simulations, standard flucloxacillin daily doses of up to 12 g may substantially enhance the risk of underdosing in critically ill patients. Prospective validation of these model predictions is needed.