Urolithin a attenuates IL-1β-induced inflammatory responses and cartilage degradation via inhibiting the MAPK/NF-κB signaling pathways in rat articular chondrocytes.
Sheng-Long DingZhi-Ying PangXue-Mei ChenZheng LiXin-Xin LiuQi-Lin ZhaiJun-Ming HuangZhi-Yong RuanPublished in: Journal of inflammation (London, England) (2020)
Our results provide the evidence that UA could attenuate IL-1β-induced cell injury in chondrocytes via its anti-inflammatory action. UA may be a promising therapeutic agent in the treatment of OA.
Keyphrases
- signaling pathway
- oxidative stress
- diabetic rats
- high glucose
- pi k akt
- anti inflammatory
- extracellular matrix
- drug induced
- single cell
- induced apoptosis
- epithelial mesenchymal transition
- endothelial cells
- cell therapy
- immune response
- nuclear factor
- knee osteoarthritis
- mesenchymal stem cells
- toll like receptor
- inflammatory response
- combination therapy
- smoking cessation
- stress induced