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Venous thromboembolism risk in patients with hormone receptor-positive HER2-negative metastatic breast cancer treated with combined CDK 4/6 inhibitors plus endocrine therapy versus endocrine therapy alone: a systematic review and meta-analysis of randomized controlled trials.

Kyaw Zin TheinThura Win HtutSomedeb BallSriman SwarupAnita SultanThein Hlaing Oo
Published in: Breast cancer research and treatment (2020)
Our meta-analyses demonstrated that the addition of CDKIs to ET in patients with HR-positive HER 2-negative MBC contribute to a higher incidence of VTE. Further trials are required to define the actual relation and definitive incidence of VTE with different CDKIs.
Keyphrases
  • venous thromboembolism
  • metastatic breast cancer
  • direct oral anticoagulants
  • meta analyses
  • risk factors
  • systematic review
  • squamous cell carcinoma
  • mesenchymal stem cells
  • cell proliferation
  • replacement therapy