Genetic and Neurophysiological Biomarkers of Neuroplasticity Inform Post-Stroke Language Recovery.

Haley C DresangDenise Y HarveySharon X XiePriyanka P Shah-BasakLaura DeLorettaRachel WurzmanShreya Y ParchureDaniela SacchettiOlufunsho FaseyitanFalk W LohoffRoy H Hamilton

Published in: Neurorehabilitation and neural repair (2022)

Neurophysiological indicators and genetic biomarkers of neuroplasticity improved aphasia severity predictions. Furthermore, BDNF polymorphism interacted with cortical excitability and stimulation-induced neuroplasticity to improve predictions. These findings provide novel insights into mechanisms of variability in stroke recovery and may improve aphasia prognostics.

Keyphrases

genome wide
atrial fibrillation
copy number
high glucose
transcranial direct current stimulation
dna methylation
stress induced
brain injury
subarachnoid hemorrhage