Naltrexone accelerated oral traumatic ulcer healing and downregulated TLR-4/NF-kB pathway in Wistar rats.

Liova Chabot DiazPaulo Goberlânio de Barros SilvaThinali Sousa DantasMário Rogério Lima MotaAna Paula Negreiros Nunes AlvesMaria Imaculada de Queiroz RodriguesKarine Cestaro MesquitaOsias Vieira de Oliveira FilhoFabrício Bitu Sousa

Published in: Archives of oral biology (2024)

Naltrexone enhanced traumatic oral ulcer healing by reducing TLR-4/NF-kB signaling and promoting fibroblast proliferation and collagen deposition. Additionally, naltrexone reduced pain in rats.

Keyphrases

signaling pathway
nuclear factor
spinal cord injury
toll like receptor
inflammatory response
lps induced
alcohol use disorder
immune response
pi k akt
chronic pain
oxidative stress
neuropathic pain
pain management
cell proliferation
postoperative pain