Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer.

Varun Sasidharan NairReem SalehSalman M ToorRowaida Z TahaAyman A AhmedMohamed A KurerKhaled MurshedNehad M AlajezMohamed Abu NadaEyad Elkord

Published in: Clinical epigenetics (2020)

This study provides novel insights into the epigenetic regulations and other molecular pathways in different myeloid cell subsets within the CRC tumor microenvironment (TME), giving opportunities to potential targets for therapeutic benefits.

Keyphrases

dna methylation
single cell
gene expression
cell therapy
rna seq
genome wide
peripheral blood
acute myeloid leukemia
stem cells
risk assessment
mesenchymal stem cells
single molecule