Bioactive Plasma Mitochondrial DNA Is Associated With Disease Progression in Scleroderma-Associated Interstitial Lung Disease.
Changwan RyuAnjali WaliaVivian OrtizCarrighan PerrySam WooBenjamin C ReevesHuanxing SunJulia WinklerJean E KanyoWeiwei WangMilica VukmirovicNicholas RisticEric A StrattonSita Ram MeenaMaksym MinasyanDaniel KurbanovXinran LiuTuKiet T LamGiuseppina FarinaJose L GomezMridu GulatiErica L HerzogPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
These findings demonstrate a previously unrecognized connection between EV-encapsulated mtDNA, clinical outcomes, and intracellular DNA-sensing PRR activation in SSc-ILD. Further study of these interactions could catalyze novel mechanistic and therapeutic insights into SSc-ILD and related disorders.