Chromatographic separation of silver-111 from neutron-irradiated palladium target: toward direct labeling of radiotracers.
Marianna TosatoAndrea GandiniSteffen HappelMarine BasAntonietta DonzellaAldo ZenoniAndrea SalviniAlberto AndrighettoValerio Di MarcoMattia AstiPublished in: EJNMMI radiopharmacy and chemistry (2023)
The developed separation method was suitable to obtain silver-111 with high molar activity in a ready-to-use water-based formulation that can be directly employed for the labeling of radiotracers. By successfully establishing a robust and efficient production and purification method for silver-111, this research paves the way for its wider application in targeted radionuclide therapy and precision imaging.