Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma.

Weiren LiuHuqiang WangQianfu ZhaoChenyang TaoWeifeng QuYushan HouRun HuangZimei SunGui-Qi ZhuXifei JiangYuan FangJun GaoXiaoling WuZhixiang YangRongyu PingJiafeng ChenRui YangTianhao ChuJian ZhouJia FanZheng TangDong YangYinghong Shi

Published in: Cancer communications (London, England) (2023)

Via multiomics analyses, we identified three metabolic subtypes of iCCA, revealing that the S2 subtype exhibited the poorest survival outcomes. We further identified DGKA as a potential target for the S2 subtype.

Keyphrases

tyrosine kinase
gene expression
risk assessment
climate change