Praelolide markedly alleviated synovial inflammation and bone destruction in CIA mice by enhancing catalase activity and activating the Nrf2 pathway to reduce disease-related ROS accumulation, highlighting praelolide as a promising candidate for multitarget treatment of RA.
Keyphrases
- oxidative stress
- rheumatoid arthritis
- diabetic rats
- signaling pathway
- dna damage
- high glucose
- cell death
- reactive oxygen species
- type diabetes
- drug induced
- high fat diet induced
- ankylosing spondylitis
- endothelial cells
- postmenopausal women
- adipose tissue
- body composition
- systemic lupus erythematosus
- interstitial lung disease
- idiopathic pulmonary fibrosis