Macrophage migration inhibitory factor exerts pro-proliferative and anti-apoptotic effects via CD74 in murine hepatocellular carcinoma.

Theresa H WirtzAlena SaalIrina BergmannPetra FischerDaniel HeinrichsElisa F BrandtMaria T KoenenSonja DjudjajKai M SchneiderPeter BoorRichard BucalaRalf WeiskirchenJürgen BernhagenChristian TrautweinMarie-Luise Berres

Published in: British journal of pharmacology (2021)

We identified a pro-tumorigenic role of MIF during proliferation and therapy-induced apoptosis of HCC cells. These effects were mediated via the MIF cognate receptor CD74. Thus, inhibition of the MIF/CD74 axis could represent a promising target with regard to new pharmacological therapies aimed at HCC.

Keyphrases

induced apoptosis
signaling pathway
endoplasmic reticulum stress
oxidative stress
anti inflammatory
cell death
cell cycle arrest
heat shock