Treatment with adipose tissue-derived mesenchymal stem cells exerts anti-diabetic effects, improves long-term complications, and attenuates inflammation in type 2 diabetic rats.

Songyan YuYu ChengLinxi ZhangYaqi YinJing XueBing LiZhengyuan GongJieqing GaoYi-Ming Mu

Published in: Stem cell research & therapy (2019)

Multiple intravenous infusions of ADSCs produced significant protective effects against long-term T2DM complications by alleviating inflammation and promoting tissue repair. The present study suggests ADSCs may be a novel, alternative cell therapy for long-term diabetic complications.

Keyphrases

adipose tissue
oxidative stress
risk factors
type diabetes
stem cells
high dose
high fat diet
skeletal muscle
glycemic control
combination therapy
weight loss
smoking cessation
replacement therapy