The urine biomarker panel [IGFBP7]x[TIMP-2] (NephroCheck® parameter) does not correlate with IGFBP7 and TIMP-2 gene expression in urinary sediment.

Daniela GergesMarkus MüllerSahra PajendaZeynep GencManfred HeckingLudwig Wagner

Published in: PloS one (2017)

The gene expression pattern of IGFBP7 and TIMP-2 from urinary sediment, which contains desquamated renal tubular epithelial cells, did not correlate with [IGFBP7]x[TIMP-2] protein, indicating that IGFBP7 and TIMP-2 measured in the NephroCheck® test originated predominantly from intact but stressed cells of the kidney itself.

Keyphrases

gene expression
dna methylation
heavy metals
induced apoptosis
cell death
oxidative stress
binding protein
protein protein
small molecule
endothelial cells